Setup
Print, cut, and sleeve 6 copies of the card sheets before play.
Before playing the Chemical X Edition, print 6 copies of the card sheets, cut the cards out, and sleeve them in standard deck protectors. This prepares all Powerpuff Girl versions, Ally cards, and Nemesis cards for play.
Setup
Each player secretly selects one version of each Powerpuff Girl and one Ally, then all reveal simultaneously.
At the start of the game, each player secretly chooses one version of each Powerpuff Girl (Blossom, Bubbles, and Buttercup) and one Ally card. Once all players have chosen, everyone simultaneously reveals their selections. This creates asymmetric team compositions each game.
Setup
Shuffle all Nemesis cards and place them face-down on grey spaces as shown in the diagram.
Shuffle all Nemesis cards together, then place them face-down on the grey spaces on the board as indicated by the setup diagram. Townsville Tiles are distributed as normal per the base game. Grey spaces correspond to villain locations across the city.
Setup
The number of villains required to win scales with player count.
The win condition (number of villains to capture) is determined by player count: 2 players must capture 5 villains; 3 players must capture 5 villains; 4 players must capture 5 villains; 5 players must capture 4 villains; 6 players must capture 4 villains.
Special
During your turn, when moving or battling with Girls, you may activate all present Girls' abilities.
During your turn, whenever you move or battle with one or more Powerpuff Girls, you may choose to activate the abilities of all Powerpuff Girls present in that action. Each Powerpuff Girl may only use her own abilities — she cannot use another Girl's ability. Movement powers cannot be activated when playing a location card.
Restriction
Movement powers cannot be used when playing a location card.
Powerpuff Girl movement powers are restricted from activation when the action being taken is playing a location card. Only movement taken as a standard move action or battle movement qualifies for movement power activation.
Card play
Ally card abilities may be used at any time; the card is discarded after use.
You may use the ability on your Ally card at any time (subject to each card's specific timing text). Once the Ally ability is used, the Ally card is discarded. Each player has one Ally card per game, so use it wisely.
Special
Landing on a Nemesis space reveals both the Nemesis card and tile; resolve the Nemesis effect first, then the tile.
When one or more Powerpuff Girls land on a space with a Nemesis card, reveal both the Nemesis card and the Townsville Tile beneath it. Resolve the Nemesis card effect first, then use the Townsville Tile as normal. When the tile is removed from the space, the Nemesis card is also removed.